Anna Mattout, Yair Aaronson, Sailaja BS, Edupuganti V Raghu Ram, Arigela Harikumar, Jan-Philipp Mallm, Kae Hwan Sim, Emmanuelle Supper, Prim B.

Intrabody-mediated sequestering of HP1b into insoluble aggregates induces co-aggregation of H3-H4 histones and LBR in the cytoplasm.

Alessio Cardinale, Ilaria Filesi, Prim B.

Heterochromatin and molecular mechanisms of parent-of-origin effects in animals. Activity DEPendent Transposition (ADEPT) and the Aging Brain. Newman Andrew, Bessa Paraskevi, Tarabykin, Victor and Singh, Prim, B.Singh, Lourdes Serrano and Alejandro An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions. Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez-Nieto, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P.Activity DEPendent Transposition (ADEPT). Newman, Andrew, Bessa, Paraskevi, Tarabykin, Victor and Singh, Prim, B.A distinctive contribution of HP1 isoforms to pericentric heterochromatin structure and organization. Singh, Lourdes Serrano and Alejandro Vaquero. Brown, Antonio Gómez, Juan Ausió, Timo Zimmermann, Manel Esteller, Gunnar Schotta, Prim B. Thackra, Carmen Casal, Jèssica González, Noriko Kane-Goldsmith, Miguel Vizoso, Jeremy P. Laia Bosch-Presegué, Helena Raurell-Vila, Joshua K.Deletion of HP1g in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth. Kyohei Oyama, Danny El‑Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P.L chromosome behaviour and chromosomal imprinting in Sciara coprophila. Age reprogramming and epigenetic rejuvenation. Maternal regulation of chromosomal imprinting in animals. He has continued this work on reprogramming, under a broader program of epigenetics, in Germany, first at a Leibniz Institute Hamburg and then, latterly, at the Charite Medical School in Berlin. This work was done in the wake of the discovery of mammalian cloning – “Dolly-the-sheep”. He then moved to Edinburgh to study nuclear reprogramming, which is the process by which a specialized cell re-acquires developmental and ageing potential.

Professor Singh’s work has done much to clarify the role mammalian HP1 chromo-domain proteins in genome organization and gene expression. CD proteins are now recognized as key epigenetic regulators of gene activity in Eukaryotes ranging from fission yeast to man. He remained in Cambridge for two decades where he demonstrated that the chromo-domain (CD) protein motif, shared by two Drosophila proteins, is conserved in animals and plants. This has profound consequences for mating preference and kin recognition.

His doctoral work concerned the olfactory recognition of genetic individuality, where he showed that the major histocompatibility complex (MHC) gives rise to odors that provide a life-long label of identity. Professor Prim Singh received his PhD from the University of Cambridge in 1987.

Jessica prim